Sinan GURA

Our group focused on the study of the structural biology by X-Ray Crystallography of EGFR and HER2, two ErbB
receptors involved mainly in non-small cell lung cancer and breast cancer.

I have become familiar with every step of protein production and purification and protein crystallization (cell culture, gene expression induction, cell lysis, purification with AKTA (Ni-NTA & SEC), ammonium sulfate precipitation, SDS-PAGE, microbatch protein crystallization).

I participated to the redaction of a
review paper on the structural biology of EGFR and HER2 and their relevance
to NSCLC as co-author. The review is currently being reviewed.

• The lab work focused on the structural biology of EGFR and HER2, two ErbB receptors involved mainly in non-small cell lung cancer and breast cancer
• The lab is specialized in X-ray crystallography
• I have become even more familiar with protein production in E.coli, protein purification (Ni-NTA & SEC) and protein crystallization
• I have also participated to the redaction of a review paper on the structural biology of EGFR and HER2 and their relevance to NSCLC as co-author
• The review is currently being reviewed.

Tutored in chemistry and biology to 1st year undergraduate students at university.

I have learnt to approach a given subject from different angles, which improved my overall ability to solve problems.

In MICA (Microscopic Imaging of Macromolecular Assemblies) group, we studied the LdcI-RavA-ViaA triad involved in acid-stress response and antibiotic resistance

Became familiar with important lab techniques, protein purification (AKTA), negative stain and cryogenic electron microscopy, single molecule localization microscopy, and data processing of cryoEM data.

Fields of bioinformatics, genetics, and ecology.

I worked on the alignment the DNA sequences of sedimentary and migratory Caucasian bears from Eastern Turkey.

I discovered DNA alignment using Bash & Linux.

I gave personalized tutoring in mathematics, chemistry and biology to high school students.

This helped me consolidate my scientific elementary knowledge as well as my capacities af transferring my knowledge.