Orgeta Zejneli
Paris
Summary
Results-driven Neuroscientist with analytical expertise across multi-cultural settings, in the innate immune system, brain-related proteinopathies, protein-protein interaction, immunotherapy, clinical diagnosis, and biomarkers in neurodegenerative diseases. Well-versed in conducting investigations of the potential therapeutic role of single-domain antibodies directed against tau in Alzheimer's disease and related tauopathies. An active coach and guide for students studying pharmacology and neuroimmune interactions. Strong critical thinker with high-quality communication and team collaboration skills. An active contributor to the team goals and team cohesion. Committed to a positive and strong work ethic.
Overview
14
14
years of professional experience
Work History
Post-Doctoral Researcher
Institute Pasteur
Paris
09.2022 - 08.2024
- Characterization of microglial and neutrophil transcriptomic profiles in an α-Syn mouse model and stroke patient samples, respectively
- Dual collaboration with the Hellenic Institute Pasteur and Rothschild Hospital.
- Mouse intracardiac perfusion, FACS-sorting, Bulk sequencing, qPCR,
- Ethical reports, and lab managing responsibilities.
- Oral and Poster Presentations in national-level symposia
- Journal review, literature review, and manuscript writing.
- Ability to achieve project goals within short deadlines.
- Chief Party Officer: Organizing team building activities, lab retreats
- Team representative in the Neuroscience Department Animation Committee
Editorial Board Member
Science Publishing Group
New York
01.2022 - 01.2024
- Reviewed journal content for accuracy and adherence to standards.
- Edited written material to improve clarity and readability
Educational Staff
Metropolitan College of Greece
01.2022 - 01.2023
- Conducting engaging lectures to introduce the basics of immunology.
- Constructive feedback on student's performance and progress
Ph.D. Student
Lille Neuroscience and Cognition (LilNCog)
Lille
01.2018 - 01.2021
- Evaluated and analyzed both in vitro (cellular) and in vivo (humanized mouse model), as part of the pre-clinical drug development testing, the potential therapeutic role of novel single-domain antibodies (VHHs) directed against tau in tauopathies, including Alzheimer’s disease (AD)
- Deliberated with the knowledge of proteinopathies, protein-protein interaction, immunotherapy strategies, oral/written communication, and project management.
- Collaborating between two teams
- Presenting the project at national and international conferences (oral and poster presentations, including ADPD, and Neuro-France).
- Cloning, PCR, plasmid extraction, protein expression, western blot, ELISA, cell culture, Immunocyto/histo-chemistry, FACS, histology. Fluorescence/optical and confocal microscopy, light-sheet (iDISCO). Mouse neuroanatomy, Stereotaxic surgery, transcardial perfusions.
- FELASA-French correspondent certificate.
- Organized student-run clubs and activities.
Licensed Pharmacist
Private Pharmacy
Thessaloniki
01.2016 - 01.2018
- Advocated for patients regarding medical prescriptions and drug reception.
- Assessed patient needs for over-the-counter products such as vitamins, herbal supplements, or homeopathic remedies.
Licensed Pharmacist
Greek Ministry of Education
01.2015 - 01.2016
- Instructed and effectively guided students regarding Pharmacology in Nutrition and Dietary unit for one semester.
Research Associate - European JPND
Aristotle University of Thessaloniki, Faculty of Pharmacy
Thessaloniki
01.2012 - 01.2015
- Responsible for patients, doctors, and scientific boards' contact and collaboration
- Prepared detailed reports summarizing experimental findings.
- Performed a variety of laboratory tests on samples including PCR, ELISA, DNA sequencing, cell culture, western blotting, qPCR assays, and RT-QUIC.
- Collaborated with other scientists to develop new methods for analyzing data.
Research Associate (Undergraduate Student)
Aristotle University of Thessaloniki, Faculty of Pharmacy
Thessaloniki
01.2011 - 01.2012
- Processed CSF samples from possible sCJD cases
- Working in a P3 security level room
Education
Ph.D. in Neuroscience -
INSERM
09-2021
BSc Faculty of Pharmacy -
Aristotle University of Thessaloniki
01.2014
MSc in Pharmaceutical & Pharmacological Sc. -
University of KU- Leuven
06-2013
Skills
- Scientific Research & Development
- Neuroimmunology & Therapeutics
- Clinical Research & Biomarkers
- Drug Development & Regulations
- Pharmacy & Pharmacology
- Project & Operations Management
- Health & Safety Standards
- Drafting reports & Presentation
Languages
- English, Proficient
- Greek, Proficient
- French, Intermediate
- Albanian, Native
Awards
- Excellence Award to Aristotle Team of Pharmacy (Co-Founder), Aristotle University of Thessaloniki, Thessaloniki
- ERASMUS scholarship, KU- Leuven, Leuven
Volunteer Experience
- Aristotle Team of Pharmacy (ATP), Thessaloniki, 2014-05-01, co-founder
- Chemistry Classes to the final year of high school students, Thessaloniki, 2016-09-01, 2017-07-01
- Young Researchers in Life Sciences- (YRLS), Paris, 2022-09-01, 2023-07-01
Publications
- Justine Mortelecque ,Orgeta Zejneli et al. J Biol Chem 2024 Mar 12:107163. https://doi: 10.1016/j.jbc.2024.107163
- Orgeta Zejneli et al. Multi-variable approach to gain increased sCJD premortem diagnosis in a cohort of Greek patients with suspected sCJD. Currently under revision.
- Clément Danis*, Elian Dupré*, Orgeta Zejneli* et al. Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment. Mol.Therapy. 2022 Jan 7; S1525-0016(22)00009-0. https://doi.org/10.1016/j.ymthe.2022.01.009.PMID: 35007758 * Equal contribution
- Pascale Barbier, Orgeta Zejneli et al. Landrieu Role of Tau as a Microtubule-Associated Protein: Structural and Functional Aspects. Frontiers Ageing Neuroscience. 2019 Aug 7; 11:204. https://doi.org/10.3389/fnagi.2019.00204. PMID: 31447664
- Llorens F, Kruse N, Schmitz M, Gotzmann N, Golanska E, Thüne K, Zejneli O et al. Evaluation of α-synuclein as a novel cerebrospinal fluid biomarker in different forms of prion diseases. Alzheimer's Dementia. 2017 June;13(6):710-719. https://doi.org/10.1016/j.jalz.2016.09.013. Epub 2016 Nov 18. PMID: 27870938
Timeline
Post-Doctoral Researcher
Institute Pasteur
09.2022 - 08.2024
Editorial Board Member
Science Publishing Group
01.2022 - 01.2024
Educational Staff
Metropolitan College of Greece
01.2022 - 01.2023
Ph.D. Student
Lille Neuroscience and Cognition (LilNCog)
01.2018 - 01.2021
Licensed Pharmacist
Private Pharmacy
01.2016 - 01.2018
Licensed Pharmacist
Greek Ministry of Education
01.2015 - 01.2016
Research Associate - European JPND
Aristotle University of Thessaloniki, Faculty of Pharmacy
01.2012 - 01.2015
Research Associate (Undergraduate Student)
Aristotle University of Thessaloniki, Faculty of Pharmacy
01.2011 - 01.2012
Ph.D. in Neuroscience -
INSERM
BSc Faculty of Pharmacy -
Aristotle University of Thessaloniki
MSc in Pharmaceutical & Pharmacological Sc. -
University of KU- Leuven
Similar Profiles
Ousmane SOWOusmane SOW
PhD internship at Pasteur Institute of DakarPhD internship at Pasteur Institute of Dakar
AMINATOU ABDOUL AZIZ AMADOU BAWAAMINATOU ABDOUL AZIZ AMADOU BAWA
PhD Candidate at Pasteur Institute of DakarPhD Candidate at Pasteur Institute of Dakar
Aime KikwanzaAime Kikwanza
Gestionnaire De L'église at Pasteur InstituteGestionnaire De L'église at Pasteur Institute