Omos Festus Obakpolor

• Design of delta-opioid receptor agonist for the treatment of chronic pain
• Design and execute novel synthetic route for the first enantioselective total synthesis of the potential ẟ-opioid receptor agonist candidate TAN-67 and its analogs
• Enantioselective ligand syntheses for the key step palladium-catalyzed asymmetric conjugated addition
• Scaling up every synthetic step up to 10g scale
• Racemic syntheses of the potential ẟ-opioid receptor agonist candidate TAN-67 and its analogs
• Biweekly presentation of research results
• Biweekly presentation of latest literature review in organic chemistry
• Weekly problem solving session-synthetic route and retrosynthesis of complex organic compounds
• Ensure the maintenance and qualifications of laboratory equipments
• Supervised undergraduate student enhancing their understanding of the subject matter.

Reference: Dr. Altman Ryan, Borch department of Medicinal Chemistry and Molecular Pharmacology. Email: raaltman@purdue.edu

• Synthesis of novel rationally designed small molecules for therapeutic purposes
• Synthesis of novel rationally designed scaffolds able to bind to the todalam site and optimization of the developed scaffolds by applying the covalent targeting strategy
• Strong adaptability skills with high proficiency in team work on collective projects for the synthesis and biological evaluation of microtubules binders
• Participated in regular team meetings; shared progress updates and received constructive feedback.
• Prepared presentations, effectively communicating complex findings to peers and faculty.

Reference: Pr. Daniele Passarella, Department of chemistry, Email: daniele.passarella@unimi.it

Role - Engaged in interdisciplinary, critical thinking, problem solving, proposing and drafting of practical works for the new master’s student, these include:

• Solid phase peptide synthesis of biologically active peptide ( pseudoneurotensin ) and attachment of markers
• Design synthetic route and spectrophotometric study of inorganic complexes
• Complete the receipt and installation of the UV-Vis spectrophotometer
• Written operating procedures for the use of the spectrophotometer for the master’s Students
• Training Master’s Students on the use of UV-Vis spectrophotometer
• Electrochemical determination of initial mass of water soluble complexes using the controlled potential method
• Theoretical study of the Phenyl iodide Oxidative Addition to Palladium Complexes using the graphical interface “the gabedit” and the Mopac computation package. All calculations were performed at the semi empirical PM6- DH+ level
• Developed and improved courses to better serve students' needs and meet standards.

• Cyclic hydroxamic acid synthesis with chirality control
• Racemic synthesis of cyclic hydroxamic acid PIPO derivatives
• Preparation of PIPO using an enantioselective synthetic pathway in order to get the precursor in larger scale without chiral separation
• Bibliographic research and preparing detailed draft reportd for assigned studies
• Safely operated all laboratory equipment

References: Pr. Ewen Bodio, Department of chemistry, email: Ewen.Bodio@u-bourgogne.fr

• Safeguard the quality of water through scientific analysis, ensuring quality and safety standard are met
• Carry out analytical checks on products from ongoing production and active ingredients
• Prepared detailed documentation of test results for reference and verification purposes.
• Conducted field investigations to collect water samples for laboratory analysis.