Summary
Overview
Work History
Education
Skills
SOFT SKILLS
LANGUAGES
ACTIVITIES AND INTERESTS
PUBLICATIONS
Timeline
Generic
LUCIA D'AURIA

LUCIA D'AURIA

Grenoble

Summary

Deputy Head of Crystallography with a PhD in structural biology and a strong background in CRO operations, client-facing project delivery, and scientific coordination. Leads crystallography work from scoping to invoicing, supporting data collection, workflow improvement, and high-quality results for drug discovery clients.

Overview

3
3
Languages
7
7
years of professional experience

Work History

Deputy Head of Crystallography

ALPX
Grenoble
01.2025 - Current
  • Oversee end-to-end crystallography projects and daily CRO operations while leading key client interactions from scoping to invoicing. Contribute to company strategy, workflow optimisation, and high-throughput data collection to drive service quality, project delivery, and business growth.

Research Scientist

ALPX
Grenoble
01.2024 - 12.2025
  • Managed client-facing crystallography projects in a CRO setting, serving as the primary point of contact for routine technical updates. Coordinated synchrotron data collection, experimental execution, and structure determination to ensure timely project delivery for biopharma clients

Deputy Head of Crystallography

MepAnti Marie Sklodowska-Curie ITN (EU Horizon 2020)
Grenoble
01.2021 - 12.2023

Biophysical and structural characterisation of two 4Fe-4S enzymes (IspG and IspH) in complex with their inhibitors to support rational drug discovery, under the supervision of Dr. Franck Borel. As part of the international MepAnti training network, completed collaborative research stays across leading European institutes.

  • Internship, Drugs for Neglected Diseases Initiative - Geneva, Switzerland 01/2023 - 02/2023

Homology modeling studies on TMEM16F ion channel, under the supervision of Dr. Charles Mowbray and Dr. Peter Sjo

  • Visiting PhD Student, HIPS Helmholtz-Institut für Pharmazeutische Forschung Saarland - Saarbrucken, Germany 03/2022 - 05/2022

Surface Plasmon Resonance (SPR) fragment screening of IspD, a Mg2+ dependent enzyme, under the supervision of Prof. Anna Hirsch

  • Visiting PhD Student, Université de Strasbourg - Strasbourg, France 09/2021 - 11/2021

Protein purification under anaerobic conditions (glove-box), under the supervision of Dr. Myriam Seemann

Deputy Head of Crystallography

Sapienza Università di Roma
Roma
09.2019 - 07.2020
  • Characterisation functional and structural aspects of cytochrome P450 using X-ray crystallography, UV-vis spectroscopy, and molecular biology techniques, contributing to understanding of enzyme mechanisms.

Education

Ph.D. - Structural Biology

Université Grenoble Alpes
Grenoble, France
12-2023

Master degree - Chemistry of biological systems

Sapienza Università di Roma
Roma
07-2020

Bachelor degree - Chemistry

Sapienza Università di Roma
Roma
07-2018

Diploma -

Liceo scientifico B. Touschek
Roma
06-2015

Skills

  • Protein Production: Protein expression, purification, incl anaerobic handling (glove box operations)
  • Crystallography: Protein crystallisation and optimisation (aerobic/anaerobic), X-ray fragment screening, synchrotron data collection
  • Biophysical characterisation: UV-Vis spectroscopy, spectrofluorimetry, Surface Plasmon Resonance (SPR), MicroScale Thermophoresis (MST)
  • Software & Structure Determination: Coot, Phenix, CCP4, PyMOL, UCSF Chimera

SOFT SKILLS

  • Flexibility
  • Team work attitude
  • Organizational skills
  • Responsibility
  • Problem-solving

LANGUAGES

Italian: First language
Proficient
C2
English: C1
Advanced
C1
French: C1
Advanced
C1

ACTIVITIES AND INTERESTS

  • Volleyball
  • Cooking
  • Literature
  • Painting
  • Travelling

PUBLICATIONS

  • Willocx D, D'AURIA L., Walsh D, Scherer H, Alhayek A, Hamed MM, Borel F, Diamanti E, Hirsch AKH. Fragment Discovery by X-Ray Crystallographic Screening Targeting the CTP Binding Site of Pseudomonas Aeruginosa IspD. Angew Chem Int Ed Engl. 2025 Feb 3;64(6):e202414615. doi: 10.1002/anie.202414615. Epub 2025 Jan 2. Erratum in: Angew Chem Int Ed Engl. 2025 Aug 4;64(32):e202514238. doi: 10.1002/anie.202514238. PMID: 39676054; PMCID: PMC11796317.
  • Montemiglio, L. C., Gugole, E.; Freda, I.; Exertier, C.; D'AURIA L.; Chen, C. G.; Nardi, A. N.; Cerutti, G.; Parisi, G.; D'Abramo, M.; Savino, C.; Vallone, B. Point Mutations at a Key Site Alter the Cytochrome P450 OleP Structural Dynamics. Biomolecules 2021, 12 (1), 55. https://doi.org/10.3390/biom12010055
  • Paris, G.; Freda, I.; Exertier, C.; Cecchetti, C.; Gugole, E.; Cerutti, G.; D'AURIA L.; Macone, A.; Vallone, B.; Savino, C.; Montemiglio, L. Dissecting the Cytochrome P450 OleP Substrate Specificity: Evidence for a Preferential Substrate. Biomolecules 2020, 10 (10), 1411. https://doi.org/10.3390/biom10101411

Timeline

Deputy Head of Crystallography

ALPX
01.2025 - Current

Research Scientist

ALPX
01.2024 - 12.2025

Deputy Head of Crystallography

MepAnti Marie Sklodowska-Curie ITN (EU Horizon 2020)
01.2021 - 12.2023

Deputy Head of Crystallography

Sapienza Università di Roma
09.2019 - 07.2020

Ph.D. - Structural Biology

Université Grenoble Alpes

Master degree - Chemistry of biological systems

Sapienza Università di Roma

Bachelor degree - Chemistry

Sapienza Università di Roma

Diploma -

Liceo scientifico B. Touschek
LUCIA D'AURIA