LEA SAKR
Paris
Summary
Postdoctoral researcher in neuro-oncology with extensive expertise in molecular and cellular biology, animal experimentation, and data analysis. Proven project management skills and effective communication abilities. Committed to leveraging advanced research methodologies to drive scientific advancements and improve patient outcomes.
Overview
7
7
years of professional experience
9
9
years of post-secondary education
Work History
Postdoctoral Researcher - Neuro-oncology
BRIGHT Lab - Paris Brain Institute
Paris
10.2023 - Current
Currently designing and conducting high-impact research projects aimed at uncovering novel therapeutic targets for brain tumors and is funded by the Fondation de France.
- Developed experimental 3D autologous immune glioblastoma organoids to study cellular interactions within the tumor microenvironment, and evaluate therapeutic responses.
- Analyzed complex datasets (snRNA-seq, bulk RNA-seq) to identify potential targets to overcome immune resistance in brain tumors.
- Contributed to the development of research proposals, securing external funding.
- Collaborating closely with a multidisciplinary team enhances the research output and fosters innovative approaches to treatment.
Doctoral Researcher - Oncology
BIOSCAR Lab - INSERM U1132
Paris
10.2019 - 10.2023
Managed two PhD projects with financial support from the Fondation pour la Recherche Médicale, focusing on the role of bone-forming cells in breast cancer progression using several mouse models.
- Performed orthotopic breast tumor transplants and intracardiac injections of breast cancer cells in mice
- Monitored breast cancer progression in mice through bioluminescent imaging.
- Conducted histological analyses on mouse specimens.
- Performed co-culture experiments with primary bone-derived cells and breast cancer cells.
- Analyzed tissue-specific gene expression.
- Conducted comprehensive immune cell profiling in tumors and immune organs.
- Presented results of research projects at national and international conferences.
Research Intern
BIOSCAR Lab - INSERM U1132
Paris
01.2019 - 07.2019
Participated in a study on the role of the bone microenvironment in the systemic control of breast cancer progression using mouse models.
Research Intern
INSERM U938
Paris
03.2018 - 05.2018
Participated in a study on the role of IGF1R in tissue homeostasis in mice.
Education
Ph.D. - Oncology
University of Paris
Paris, France 10.2019 - 10.2023
Master of Science - Stem Cell Biology
Sorbonne University
Paris, France 09.2017 - 06.2019
Bachelor of Science - Biology
American University of Beirut
Beirut, Lebanon 09.2014 - 06.2017
Laboratory skills
- Primary cell isolation and culture
- Immune cell profiling
- Multi-parameter flow cytometry
- iPSC culture and differentiation
- Genetic engineering
- 3D modeling
- Drug testing
- RT-qPCR
- RNA-seq
- Animal handling
- Histological analysis
Skills
- Experimental Design
- Data Analysis
- Project Management
- Effective Communication
- Scientific writing
- Research Collaboration
Languages
French
Native language
English
Proficient (C2)
C2
Arabic
Proficient (C2)
C2
Spanish
Intermediate (B1)
B1
Scientific awards
- ASBMR Young Investigator Award - Austin, TX, 09/2022: Awarded the American Society of Bone and Mineral Research Young Investigator Fund for Education and Research at the annual meeting.
- Journées IMOA Prix de Thèse - Paris, 06/2022: Selected for the scientific award for best oral presentation at the annual scientific day of the Institute of Osteoarticular Diseases (IMOA, Institut des Maladies Ostéo-Articulaires).
- JFBTM Prix Jeune Chercheur - La Baule-Escoublac, 04/2022: Selected for the scientific award for best oral presentation at the annual meeting of the French Society of Mineralized Tissue Biology (SFBTM, Société Française de Biologie des Tissus Minéralisés).
Courses
- 5th Course on Breast Cancer - Curie Institute, Paris, 10/2022
Affiliations
- Supervisor - L'Arbre des connaissances: Apprentis Chercheurs - INSERM U1132, Paris, 10/2019-10/2023: Supervised high school and middle school students once a week to help them discover laboratory work and develop their critical thinking skills.
- Teaching assistance, PACES - UFR de médecine, Paris, 10/2019-10/2023: Taught PACES students cell and molecular biology classes.
- Co-founder and editor, AUB Biology Department E-Newsletter - American Univeristy of Beirut, Beirut 02/2017 - 06/2017: Highlight research and educational activities of the AUB Biology department.
- Cabinet member: Secretary, Biology Student Society - American University of Beirut, Beirut 10/2016 - 06/2017: Organize academic and recreational events.
- Founder and member, Roumieh Youth Committee, Roumieh - Lebanon, 09/2016 - 09/2017: Organize cultural events in Roumieh to bring citizens together.
References
References available upon request.
Timeline
Postdoctoral Researcher - Neuro-oncology
BRIGHT Lab - Paris Brain Institute
10.2023 - Current
Ph.D. - Oncology
University of Paris
10.2019 - 10.2023
Doctoral Researcher - Oncology
BIOSCAR Lab - INSERM U1132
10.2019 - 10.2023
Research Intern
BIOSCAR Lab - INSERM U1132
01.2019 - 07.2019
Research Intern
INSERM U938
03.2018 - 05.2018
Master of Science - Stem Cell Biology
Sorbonne University
09.2017 - 06.2019
Bachelor of Science - Biology
American University of Beirut
09.2014 - 06.2017
Similar Profiles
Adejoke JolaosoAdejoke Jolaoso
Support worker at BRIGHT BRAIN GLOBALSupport worker at BRIGHT BRAIN GLOBAL
Hanzhang LyuHanzhang Lyu
Lab Assistant at The Brain Cognition And Brain Disease InstituteLab Assistant at The Brain Cognition And Brain Disease Institute
Depsy Ann FelicanoDepsy Ann Felicano
Finance Staff Member at Bright and Brain Technologies Sevices Corp.Finance Staff Member at Bright and Brain Technologies Sevices Corp.