Ameni SDIRI
Senior R&D scientist
Evry
Profil professionnel
Experienced professional in process development, specializing in USP/DSP optimization for protein production. Proven expertise in leading and training technical teams as well as managing technical transfer processes for large manufacturing. Strong communicator with a focus on setting clear objectives and delivering results through effective leadership and teamwork.
Vue d'ensemble
9
9
years of professional experience
1
1
year of post-secondary education
Expérience professionnelle
USP/DSP Process development Scientist
Univercells
Evry
08.2020 - 12.2024
- Production of recombinant proteines using E.coli and CHO cells
- Tripled product yield at small scale and successfully scaled up
- Provided Leadership and management of the technical team( 2 technicians)
- Delivered project milestones by setting clear targets and regular follow-ups via weekly meetings
- Conducted risk analysis and assessment to ensure project progress on time and within the budget
- Facilitated cross-functional communication with production support teams, including QC, QA, and Supply Chain
- Collaborated with industrialization engineers for process technology transfer, including preparing Batch Records (BR), Methods of Procedure (MOP), certificat of Analysis (CoA), and Quality Assurance (QA) documentation
Biological Engineer
Brain institute of Paris
Paris
04.2019 - 07.2020
- Investigated the effect of homeopathic molecules on primary cells in collaboration with a pharmaceutical company
- Primary Cell Isolation, Cell culture and transfection
- Setting up an action plan ( Gantt, deadline, project steps)
- Writing protocols, reports and oral presentation
- Analytics skills, risk analysis, problem-solving
- Collaborate with external service providers to maintain reagents supplies for project
- Lab management ( maintained inventory, trained 3 students)
Research intern
INRA
France
01.2016 - 07.2017
Research intern
Institut Jacques Monod
France
11.2015 - 07.2016
Formation
Master's Degree - Transplantation Immunology
Medical School
09.2016 - 06.2017
Master's Degree - Biological Platform Engineering
Paris Diderot
09.2015 - 06.2016
Compétences
Cell culture ( CHO, HEK293, glial cells, bacteria Ecoli )
Bacterial transformation ( heat shock, electroporation, plasmid cloning)
Recombinant protein production ( Ecoli, CHO cells, expression optimization)
Molecular biology techniques ( PCR, DNA/protein extraction, western blot, ELISA, SDS-PAGE)
Proficient in operating AKTA avant 150 and AKTA pure chromatography systems
Documentation ( experimental report, checklist, MOP, BR, MBR and SOPs)
Leading and training technicals teams
Supervising performance and development of teams ( one-to-one meeting,define SMART goals, constructive feedback)
Troubleshooting & problem-solving, Root cause analysis, Risk assessment, Monitoring deliverables( IPC,QC)
Establishing lab rules, Draft and implement SOPs and WI, Maintain inventory
Langues
French
Bilingue
English
Opérationnel
Spanish
Notions
Arabic
Bilingue
Informations complémentaires
- Running,Yoga,Cinema,Travel, Cooking, Reading scientific articles
Frise chronologique
USP/DSP Process development Scientist
Univercells
08.2020 - 12.2024
Biological Engineer
Brain institute of Paris
04.2019 - 07.2020
Master's Degree - Transplantation Immunology
Medical School
09.2016 - 06.2017
Research intern
INRA
01.2016 - 07.2017
Research intern
Institut Jacques Monod
11.2015 - 07.2016
Master's Degree - Biological Platform Engineering
Paris Diderot
09.2015 - 06.2016
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